Maintained drug concentration at the site of disease

ZILRETTA microspheres maintained quantifiable concentrations of triamcinolone acetonide (TA) in the synovial fluid out to 12 weeks1

Joint residence time chart
  • Results based on a study evaluating concentration of TA in synovial fluid following a single intra-articular injection of ZILRETTA® (triamcinolone acetonide extended-release injectable suspension) (n=29); synovial fluid was obtained at Weeks 1, 6, 12, 16, or 201

The clinical relevance of this synovial fluid information is unknown


Data presented as geometric mean (GM). While GM is above the limit of quantification at Weeks 6 and 12, the range includes some patients who were below the limit of quantification (BLOQ).1

TA=triamcinolone acetonide; BLOQ=below the limit of quantification; GM=geometric mean.